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SJF 1521
CAS No. 2230821-40-4
SJF 1521( —— )
Catalog No. M34826 CAS No. 2230821-40-4
SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 935 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSJF 1521
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NoteResearch use only, not for human use.
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Brief DescriptionSJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.
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DescriptionSJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPROTACs | EGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number2230821-40-4
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Formula Weight1074.65
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Molecular FormulaC57H61ClFN7O9S
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C=1C2=C(C=CC(=C2)C3=CC=C(OCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C=C3)N=CN1)C7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Burslem GM,et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.?
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