SJF 1521

CAS No. 2230821-40-4

SJF 1521( —— )

Catalog No. M34826 CAS No. 2230821-40-4

SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SJF 1521
  • Note
    Research use only, not for human use.
  • Brief Description
    SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.
  • Description
    SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs | EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2230821-40-4
  • Formula Weight
    1074.65
  • Molecular Formula
    C57H61ClFN7O9S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C=1C2=C(C=CC(=C2)C3=CC=C(OCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C=C3)N=CN1)C7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Burslem GM,et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.?
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